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Neuroblastoma UK Awards £1.1 Million in 2024 Grant Round
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Neuroblastoma UK Awards £1.1 Million in 2024 Grant Round

Neuroblastoma UK is awarding £1.1 million in its 2024 grant round to fund new innovative research into neuroblastoma. New therapeutic approaches, pathways to improve existing treatments and exploration of an MRNA vaccine are just some of the projects to be funded in the 2024 grant round; with an emphasis on translational research which can be rapidly transferred from the lab bench to bedside.

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Research partly funded by Neuroblastoma UK leads to an innovative stem cell model providing insight into childhood cancer origins
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Research partly funded by Neuroblastoma UK leads to an innovative stem cell model providing insight into childhood cancer origins

Researchers from the University of Sheffield and St. Anna Children’s Cancer Research Institute have created a model designed to investigate the origins of neuroblastoma, a cancer primarily affecting infants and young children. The findings offer hope for the creation of tailored treatments which treat aggressive neuroblastomas and minimise the adverse effects experienced by patients from existing therapies.

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New research suggests potential combination therapy option for children with neuroblastoma to prevent resistance to treatment
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New research suggests potential combination therapy option for children with neuroblastoma to prevent resistance to treatment

New research published by Professor Suzanne Turner and led by Dr Perla Pucci in her group at the University of Cambridge Department of Pathology and CRUK Cambridge Centre Paediatric Cancer Programme, has suggested a new target for combination treatment of neuroblastoma and other cancers alongside ALK tyrosine kinase inhibitors (ALK TKI). Resistance to ALK TKI is a challenge and so additional targets for treatments that can be used in combination with ALK TKI are urgently needed.

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6th Neuroblastoma UK Research Symposium focuses on the biology of neuroblastoma, aiming for more effective and less toxic treatments for children

It was sold out two months in advance, so it was no surprise to see a packed auditorium at Selwyn College Cambridge for the 6th Neuroblastoma UK Research Symposium on 21st and 22nd March 2024. Over 130 scientists and clinicians attended from across Europe, US, and further afield, including world leading experts in pre-clinical and clinical neuroblastoma research.

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Encouraging results from the study investigating the role of Enhancer of Zeste homolog 2 (EZH2) and Natural Killer cells in Neuroblastoma

In 2023, Dr Gao, working with Prof Juliet Gray and Dr Zoë Walters at the University of Southampton, aimed to determine the role of natural killer cell- mediated anti-tumour effects in neuroblastoma, after treatment with EZH2. The objectives of the study were to look at the correlation between EZH2 protein expression and the surface expression of natural killer ligands in neuroblastoma cells, and to determine if the natural killer cells induced cytotoxicity that could be enhanced in the neuroblastoma cell lines with EZH2 inhibitors.

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